San Bruno is a populated place at the Gulf of California in Mulegé Municipality in the Mexican state of Baja California Sur. It is located at , about 20 kilometers north of the city of Mulegé. The town has 623 inhabitants as per the 2010 census population and is situated at an elevation of 1 meter (3 ft.) above sea level.
The short-lived Jesuit Misión San Bruno (1683-1685) was not located near the present town of San Bruno, but more than to the south, about north of the city of Loreto.
This area has a large amount of sunshine year round due to its stable descending air and high pressure. According to the Köppen Climate Classification system, San Bruno has a desert climate, abbreviated "BWh" on climate maps.