Samuel Spencer may refer to:
- Samuel Spencer (North Carolina politician) (1734âÂÂ1794), North Carolina judge, lawyer, and Revolutionary War colonel
- Samuel M. Spencer (1875âÂÂ1960), politician on Hawaii island
- Samuel R. Spencer (1871âÂÂ1961), American politician, lieutenant governor of Connecticut
- Samuel Spencer (railroad executive) (1847âÂÂ1906), first president of the Southern Railway
- S. B. Spencer (1827âÂÂ1901), mayor of Atlanta, Georgia
- Sam Spencer (1902âÂÂ1987), English footballer
- Samuel Reid Spencer Jr. (1919âÂÂ2013), president of Davidson College
- Samuel A. Spencer, American politician in the Virginia House of Delegates
- Samuel Spencer (DC commissioner) (1910âÂÂ1997), president of the District of Columbia Board of Commissioners