Samuel Butler may refer to:
- Samuel Butler (poet) (1613âÂÂ1680), English poet and satirist
- Samuel Butler (schoolmaster) (1774âÂÂ1839), English classical scholar
- Samuel Butler (politician) (1825âÂÂ1891), American politician
- Samuel Butler (novelist) (1835âÂÂ1902), English author of Erewhon
- Samuel Butler (cricketer) (1850âÂÂ1903), English cricketer
- Samuel Butler (lawyer) (1930âÂÂ2025), American lawyer
- Sam Butler (footballer, born 1986), Australian rules footballer for West Coast
- Sam Butler (footballer, born 2003), Australian rules footballer for Hawthorn
- Bo Weavil Jackson (fl. 1926), blues singer and guitarist also known as Sam Butler