Sam Mayes (born 20 May 1994) is a former Australian rules footballer who played with the and the Port Adelaide Football Club in the Australian Football League (AFL).
Mayes made his AFL debut for Brisbane in the Round 3 match against Gold Coast in the 2013 AFL season. Mayes was nominated for the 2013 AFL Rising Star after his performance in round 12 against .
At the conclusion of the 2018 season, Mayes sought a trade back to South Australia, and was traded to on 17 October.
Mayes played his first game for Port Adelaide in Round 7 of the 2020 AFL season in a win against Carlton. Mayes was delisted at the conclusion of the 2022 AFL season.
|- style="background:#eaeaea;" ! scope="row" style="text-align:center" | 2013 | style="text-align:center" | | 32 || 18 || 12 || 5 || 198 || 103 || 301 || 87 || 45 || 0.7 || 0.3 || 11.0 || 5.7 || 16.7 || 4.8 || 2.5 |- ! scope="row" style="text-align:center" | 2014 | style="text-align:center" | | 32 || 21 || 11 || 11 || 192 || 159 || 351 || 92 || 47 || 0.5 || 0.5 || 9.1 || 7.6 || 16.7 || 4.4 || 2.2 |- style="background:#eaeaea;" ! scope="row" style="text-align:center" | 2015 | style="text-align:center" | | 32 || 14 || 2 || 5 || 108 || 94 || 202 || 68 || 28 || 0.1 || 0.4 || 7.7 || 6.7 || 14.4 || 4.9 || 2.0 |- ! scope="row" style="text-align:center" | 2016 | style="text-align:center" | | 32 || 21 || 1 || 1 || 239 || 132 || 371 || 88 || 45 || 0.0 || 0.0 || 11.4 || 6.3 || 17.7 || 4.2 || 2.1 |- style="background:#eaeaea;" ! scope="row" style="text-align:center" | 2017 | style="text-align:center" | | 32 || 21 || 0 || 1 || 270 || 170 || 440 || 127 || 38 || 0.0 || 0.0 || 12.9 || 8.1 || 21.0 || 6.0 || 1.8 |- ! scope="row" style="text-align:center" | 2018 | style="text-align:center" | | 32 || 6 || 0 || 1 || 51 || 46 || 97 || 24 || 9 || 0.0 || 0.2 || 8.5 || 7.7 || 16.2 || 4.0 || 1.5 |- class="sortbottom" ! colspan=3| Career ! 101 ! 26 ! 24 ! 1058 ! 704 ! 1762 ! 486 ! 212 ! 0.3 ! 0.2 ! 10.5 ! 7.0 ! 17.4 ! 4.8 ! 2.1