Salvia macrophylla is a perennial undershrub native to Colombia, Peru, and Bolivia. In Colombia it is a rare plant, found growing on roadside banks in the south, at elevations from .
The plant has many decumbent and upright stems reaching high and spreading into a large bush. The triangular-hastate leaves are long and wide, and violet on the underside. The leaves have many glands, and are sticky and aromatic. The corolla is blue, long, with the upper lip smaller than the lower, growing on branches.