Saltern Creek is a former rural locality in the Barcaldine Region, Queensland, Australia. In the , Saltern Creek had a population of 12 people.
On 22 November 2019, the Queensland Government decided to amalgamate the localities in the Barcaldine Region, resulting in five expanded localities based on the larger towns: Alpha, Aramac, Barcaldine, Jericho and Muttaburra. Saltern Creek was incorporated into Barcaldine.
The watercourse Saltern Creek (after which the locality is presumably named) flows through the locality from south-east (Ingberry) to south-west (Tara Station).
The principal land use is grazing on native vegetation.
On 23 March 1888, an artesian bore successfully struck a supply of fresh water at , flowing at a rate of per hour. On 17 September 1889 the No 2 bore was successful, finding fresh water at which flowed at a rate of per day, that is, per hour, "completely eclipsing" the first bore. On 31 May 1890, No 3 bore struck fresh water at flowing at per day at a temperature of .
There are no schools in Saltern Creek. The nearest primary and secondary schools are in Barcaldine.