Epworth-Great Salmonier is a local service district and designated place in the Canadian province of Newfoundland and Labrador. It is on the Burin Peninsula of the island of Newfoundland.
Epworth-Great Salmonier is in Newfoundland within Subdivision E of Division No. 2.
As a designated place in the 2016 Census of Population conducted by Statistics Canada, Epworth-Great Salmonier recorded a population of 177 living in 73 of its 86 total private dwellings, a change of from its 2011 population of 211. With a land area of , it had a population density of in 2016.
Epworth-Great Salmonier is a local service district (LSD) that is governed by a committee responsible for the provision of certain services to the community. The chair of the LSD committee is Robert Mitchell.