Sala Monferrato is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about east of Turin and about northwest of Alessandria. As of 31 December 2004, it had a population of 446 and an area of .
Sala Monferrato borders the following municipalities: Cella Monte, Cereseto, Ottiglio, Ozzano Monferrato, and Treville.