Sainte-Croix-aux-Mines (; ; ) is a commune in the Haut-Rhin department in Grand Est in north-eastern France. It is part of the arrondissement of Colmar-Ribeauvillé.
Coal mines were operating in the village until 1849.
Sainte-Croix-aux-Mines has an oceanic climate (Köppen climate classification Cfb). The average annual temperature in Sainte-Croix-aux-Mines is . The average annual rainfall is with July as the wettest month. The temperatures are highest on average in July, at around , and lowest in January, at around . The highest temperature ever recorded in Sainte-Croix-aux-Mines was on 25 July 2019; the coldest temperature ever recorded was on 20 December 2009.
Maurice Burrus, a tobacco magnate and noted philatelist, was a resident. His home there, the Château Burrus, is a French monument historique.