Sainte-Vertu () is a commune in the Yonne department in Bourgogne-Franche-Comté in north-central France.
The surrounding communes are Môlay, Poilly-sur-Serein and Aigremont. Sainte-Vertu is situated to the south-east of Auxerre which is the nearest large town.
The village is traversed by the little Serein River. The is approximately away.
Recorded population peaked at 544 in 1821, but has fallen back steadily subsequently, the decline accelerating with the mechanisation of agriculture in the twentieth century. As of 2023, the population stood at just 66.