Sainte-Marguerite-Marie () is a municipality in the Canadian province of Quebec, located in La Matapédia Regional Council Municipality. It was known as Sainte-Marguerite until October 30, 2010.
The municipality had a population of 183 at the Canada 2021 Census.
Canada Census data before 2001:
Provincially it is part of the riding of Matane-Matapédia. In the 2022 Quebec general election the incumbent MNA Pascal Bérubé, of the Parti Québécois, was re-elected to represent the population of Sainte-Marguerite-Marie in the National Assembly of Quebec.
Federally, Sainte-Marguerite-Marie is part of the federal riding of RimouskiâÂÂLa Matapédia. In the 2025 Canadian federal election, the incumbent Maxime Blanchette-Joncas of the Bloc Québécois was re-elected and began to represent the population Sainte-Marguerite-Marie in the House of Commons of Canada after the electoral district of AvignonâÂÂLa MitisâÂÂMataneâÂÂMatapédia was abolished.