Sainte-Marguerite (; Auvergnat: Senta Margarida) is a commune in the Haute-Loire department and the Auvergne region of south-central France.
Sainte-Marguerite is located in the Parc naturel régional Livradois-Forez.
The Senouire flows southwest through the southeastern part of the commune.
The commune contains several hamlets, including Le Rif, La Vizade and Charbonnières.