Saint Sophia may refer to
- Saint Sophia of Milan, feast day 17 September
- Saint Sophia of Rome, martyr, feast day 15 May
- Saint Sophia of Sortino (Sicily), martyr, feast day 23 September
- Saint Sofia of Suzdal (died 1542), see Solomonia Yuryevna Saburova
- Saint Sophia of Slutsk (died 1612), see Sophia Olelkovich Radziwill
- Sancta Sophia College, University of Sydney, Australia
- Selimiye Mosque, Nicosia, formerly Cathedral of Saint Sophia, Cyprus
See also