Saint Lucia competed at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023. This was Saint Lucia's 8th appearance at the Pan American Games, having competed at every edition of the Games since 1995.
On October 13, the Saint Lucia Olympic Committee announced a team of four athletes (three men and one woman) competing in three sports. Sailor athlete Luc Chevrier was the country's flagbearers during the opening ceremony. Meanwhile, Chevrier was also the country's flagbearer during the closing ceremony.
The following is the list of number of competitors (per gender) participating at the games per sport/discipline.
Saint Lucia qualified two track and field athletes, one per gender.
Saint Lucia qualified one boat (one male sailor).
Saint Lucia qualified one male swimmer.
Saint Lucia received a wildcard to send one male table tennis athlete. Ultimately this quota was not used.