Saint Clement is a census-designated place in Pike County, Missouri, United States, located on Route 161 approximately four miles south of Bowling Green.
The first settlement at St. Clement, named for Clement of Rome, was made in 1870 by a colony of German Catholics. A post office called Saint Clement was established in 1870, and remained in operation until 1882.
While there is no fixed-route transit service in St. Clement, intercity bus service is provided by Burlington Trailways in nearby Bowling Green.