Saint-Vincent-de-Cosse (; Languedocien: Sent Vincenç de Còssa) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France, on the Dordogne River.
The commune is located south of Sarlat-la-Canéda. It has two church buildings: an original Romanesque twelfth century church, Saint Vincent le Salvadou, and a nineteenth century replacement. It is named for St Vincent de Agen, a local third century saint.