Saint-Seurin-sur-l'Isle (, literally Saint Seurin on the Isle; ) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France. Saint-Seurin-sur-l'Isle station has rail connections to Bordeaux, Périgueux, Brive-la-Gaillarde and Limoges.
Marcel Berthomé was mayor from 1971 to 2020. From 2014 to 2020 he was the oldest mayor in France.