Saint-Santin (; Languedocien: Sent Antin), or Saint-Santin d'Aveyron, is a commune in the Aveyron department in southern France.
Since the French revolution, the town of Saint-Santin has been split into two communes in neighbouring departments, Saint-Santin d'Aveyron and Saint-Santin-de-Maurs in the department of Cantal.