Saint-Mathieu-d'Harricana (, ) is a municipality in the Canadian province of Quebec, located in the Abitibi Regional County Municipality. It is part of the census agglomeration of Amos.
The municipality is home to a bottling plant operated by Eska Water, which sources and bottles natural spring water from the surrounding region.
In the 2021 Census of Population conducted by Statistics Canada, Saint-Mathieu-d'Harricana had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
As of the 2021 census, mother tongues spoken are:
Municipal council (as of 2023):