Safe is an unincorporated community in Duplin County, North Carolina, United States.
Safe is located in southwestern Duplin County, near Wallace. The community is bordered to the south by Pender County and to the west by Sampson County.
NC 41 is the primary highway within Safe. Interstate 40 and US 117 are located to the east of the community.
The ZIP Code for Safe is 28466.
In 2023, the population estimate was 573.