ST-1936, also known as 2-methyl-5-chloro-N,N-dimethyltryptamine (2-methyl-5-chloro-DMT), is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT<sub>6</sub> receptor agonist, with a K<sub>i</sub> of 13 nM, and much weaker action at 5-HT<sub>2B</sub> and 5-HT<sub>7</sub> subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects.