List of highways numbered 580

Route 580, or Highway 580, may refer to:

Canada

• Alberta Highway 580
• New Brunswick Route 580
• Ontario Highway 580

United Kingdom

• A580 road

United States

• I-580
• Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
• Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395)
• Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska