SM UB-52 was a German Type UB III submarine or U-boat in the German Imperial Navy () during World War I. She was commissioned into the Pola Flotilla of the German Imperial Navy on 9 August 1917 as SM UB-52.
She operated as part of the Pola Flotilla based in Cattaro. UB-52 was sunk by torpedo on 23 May 1918 at by the British submarine enforcing the Otranto Barrage at the southern end of the Adriatic, with all hands lost.
UB-52 was ordered by the GIN on 20 May 1916. She was built by Blohm & Voss, Hamburg and following just under a year of construction, launched at Hamburg on 8 March 1917. UB-52 was commissioned later that same year under the command of Oblt.z.S. Otto Launburg.
Like all Type UB III submarines, UB-52 carried 10 torpedoes and was armed with a deck gun. UB-52 would carry a crew of up to 3 officer and 31 men and had a cruising range of . UB-52 had a displacement of while surfaced and when submerged. Her engines enabled her to travel at when surfaced and when submerged.