SKF-83,959, a synthetic benzazepine derivative used in scientific research, acts as an agonist at the D<sub>1</sub>âÂÂD<sub>2</sub> dopamine receptor heteromer. It behaves as a full agonist at the D<sub>1</sub> protomer and a high-affinity partial agonist at the D<sub>2</sub> protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 additionally inhibits sodium channels as well as delayed rectifier potassium channels. SKF-83,959 is a racemate that consists of the R-(+)- and S-(âÂÂ)-enantiomers MCL-202 and MCL-201, respectively.
SKF-83,959 was described as a SNDRI. The synthesis has been described.