SKF-39315 is a monoamine receptor modulator of the 3-benzazepine family. It is a cyclized phenethylamine analogue of the neurotransmitter dopamine. The drug shows affinities (K<sub>i</sub>) of 12nM for the dopamine D<sub>2</sub> receptor and 5,200nM for the dopamine D<sub>1</sub> receptor. It also has direct and indirect adrenergic actions. The 1-phenyl derivative of SKF-39315 is SKF-38393, which has reversed activities at dopamine receptors compared to SKF-39315 and acts as a selective dopamine D<sub>1</sub>-like receptor agonist. SKF-39315 was first described in the scientific literature by at least 1988.