SHR9352 is a drug which acts as a potent and selective biased agonist at the ü-opioid receptor, selective for activation of the G-protein signalling pathway over ò-arrestin 2 recruitment. It was structurally derived from oliceridine by replacing the benzylic side chain with a cyclised group, although only some compounds in the series retained the desired biased agonist profile, with some derivatives such as compound 12 being potent, unbiased ü-opioid full agonists.
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