Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1<small>D</small>-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).
This enzyme catalyses the following chemical reaction
This enzyme hydrolyses 1-phosphatidyl-1<small>D</small>-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P<sub>3</sub>) to produce PtdIns(3,4)P<sub>2</sub>.