SH-I-048A (SH-i-048A) is a benzodiazepine derivative related in structure to compounds such as flubromazepam and meclonazepam. SH-I-048A is described as a non subtype selective superagonist at the benzodiazepine site of GABA<sub>A</sub> receptors, with a binding affinity of 0.77 nM at the ñ<sub>1</sub> subtype, 0.17 nM at ñ<sub>2</sub>, 0.38 nM at ñ<sub>3</sub> and 0.11 nM at ñ<sub>5</sub>. It has been used to study the functional differences between the different subtypes of the GABA<sub>A</sub> receptor.