S. Pressly Coker House is a historic home located at Hartsville, Darlington County, South Carolina. It was built in 1917, it is a blending of elements of both the Shingle Style and Colonial Revival styles, with the form and massing of the bungalow. It is a two-story, three-bay, rectangular, shingle-clad residence. It features an engaged one-story portico which extends and wraps to form a porte-cochère. It was the home of S. Pressly Coker (1887-1953), prominent Hartsville agriculturalist and businessman who was a plant breeder with the Coker Pedigreed Seed Company and later founder and president of the Humphrey-Coker Seed Company and the Hygeia Dairy.
It was listed on the National Register of Historic Places in 1994.