Ryan Matthew Hendrix (born December 16, 1994) is an American professional baseball pitcher for the Tecolotes de los Dos Laredos of the Mexican League. He has previously played in Major League Baseball (MLB) for the Cincinnati Reds.
Hendrix attended Cypress Woods High School in Cypress, Texas. He was drafted by the Cleveland Indians in the 17th round of the 2013 MLB draft, but did not sign and attended Texas A&M University. In 2015, Hendrix played for the United States collegiate national team. Against Cuba, Hendrix, Tanner Houck, and A. J. Puk combined to throw a no-hitter. Hendrix was drafted by the Cincinnati Reds in the 5th round, with the 138th overall selection, of the 2016 MLB draft, and signed with them.
Hendrix split his professional debut season of 2016 between the Billings Mustangs and the Dayton Dragons, going a combined 3âÂÂ1 with a 3.57 ERA and 36 strikeouts over innings. He split the 2017 season between Dayton and the Daytona Tortugas, going a combined 5âÂÂ5 with a 2.90 ERA and 88 strikeouts over 62 innings. He spent the 2018 season with Daytona, going 4âÂÂ4 with a 1.76 ERA and 79 strikeouts over 51 innings. He split the 2019 season between the Arizona League Reds and the Chattanooga Lookouts, going a combined 4âÂÂ0 with a 1.85 ERA and 31 strikeouts over innings.
On November 20, 2019, the Reds added Hendrix to their 40-man roster to protect him from the Rule 5 draft. He did not play a minor league game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.
On April 23, 2021, Hendrix was promoted to the major leagues for the first time. He made his MLB debut that day, pitching a shutout inning of relief against the St. Louis Cardinals. In the game, he also recorded his first two major league strikeouts, punching out Justin Williams and Tommy Edman.
On April 24, 2022, Hendrix was designated for assignment by the Reds. He cleared waivers and was sent outright to Triple-A Louisville on April 29. He had his contract selected back to the major league roster on July 16, and was returned to the minors on July 19. He again had his contract selected on July 30. In 9 total games for Cincinnati, Hendrix recorded a 5.40 ERA with 9 strikeouts in innings pitched. On October 15, Hendrix was removed from the 40-man roster and sent outright to TripleâÂÂA Louisville. On October 20, Hendrix elected to become a free agent.
On December 9, 2022, Hendrix signed a minor league contract with the Arizona Diamondbacks. He made only three appearances for the TripleâÂÂA Reno Aces, posting a 3.00 ERA with 2 strikeouts in 3.0 innings of work. On August 30, 2023, Hendrix was released by the Diamondbacks organization.
On February 8, 2025, Hendrix signed a minor league contract with the Kansas City Royals. He made 34 appearances split between the Double-A Northwest Arkansas Naturals and Triple-A Omaha Storm Chasers, accumulating a 5-4 record and 7.84 ERA with 60 strikeouts across innings pitched. Hendrix elected free agency following the season on November 6.
On January 22, 2026, Hendrix signed with the Tecolotes de los Dos Laredos of the Mexican League.