The Russian route R254 is a federal highway in Russia and Kazakhstan and is part of the Baikal Highway (which is part of the Trans-Siberian Highway). It runs from Chelyabinsk through Kurgan, Petropavl, and Omsk until Novosibirsk, with a total length of .
The Chelyabinsk-Omsk stretch is also included into the European route E30.
Before 2018, the route was known as the M51.