The Rural Municipality of Whiska Creek No. 106 (2016 population: ) is a rural municipality (RM) in the Canadian province of Saskatchewan within Census Division No. 3 and Division No. 3. It is located in the southwest portion of the province.
The RM of Whiska Creek No. 106 incorporated as a rural municipality on January 1, 1913.
In the 2021 Census of Population conducted by Statistics Canada, the RM of Whiska Creek No. 106 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
In the 2016 Census of Population, the RM of Whiska Creek No. 106 recorded a population of living in of its total private dwellings, a change from its 2011 population of . With a land area of , it had a population density of in 2016.
The RM of Whiska Creek No. 106 is governed by an elected municipal council and an appointed administrator that meets on the second Monday of every month. The reeve of the RM is Kelly Williamson while its administrator is Teresa Richards. The RM's office is located in Vanguard.
Poverty Valley Aerodrome is located within the RM.