Rufina is a rural barrio in the municipality of Guayanilla, Puerto Rico. Its population in 2010 was 220. Rufina was established in 1935 and was made up of parts of Guayanilla barrio-pueblo and Indios barrio in Guayanilla.
Rufina has of land area and of water area. In 2010, its population was 220 with a population density of .