Roy Jacob Lopez (born August 7, 1997) is an American professional football nose tackle for the Arizona Cardinals of the National Football League (NFL). He played college football for the New Mexico State Aggies before transferring to the Arizona Wildcats. He was selected by the Houston Texans in the sixth round of the 2021 NFL draft.
Lopez was ranked as a twostar recruit by 247Sports.com coming out of high school. He committed to New Mexico State on August 23, 2016. Lopez injured his leg in the first week of the 2019 season and returned only briefly at the end of the season. He was granted a fifth year of eligibility and transferred to Arizona on July 19, 2020.
Lopez was drafted by the Houston Texans in the sixth round with the 195th pick of the 2021 NFL draft on May 1, 2021. On May 12, 2021, Lopez officially signed with the Texans. During a November 7, 2021, game against the Miami Dolphins, he sacked quarterback Jacoby Brissett and later recovered a fumble forced by teammate Kamu Grugier-Hill. They were the first sack and first takeaway of his professional career.
On August 29, 2023, Lopez was waived/injured by the Texans.
On September 23, 2023, Lopez was signed to the practice squad of the Arizona Cardinals, and promoted to the active roster three days later.
On March 11, 2025, Lopez signed a one-year, $4.65 million contract with the Detroit Lions.
On March 11, 2026, Lopez signed a two-year contract with the Arizona Cardinals.
Lopez is of Mexican-American descent. His mother and several other members of his family are police officers.