Route nationale 2 (RN2) is a primary highway in Madagascar. The route runs from the capital city of Antananarivo to Toamasina, a city on the eastern coast of the Madagascar.
The twisting route is served by taxi-brousses and buses.
In 2025, civil-society groups including Conservation International Madagascar raised environmental concerns about the Antananarivo-Toamasina highway project; the government said it would modify the route to avoid the Ankeniheny-Zahamena Corridor and other protected forests.