Roussillon-en-Morvan (; 'Roussillon-in-Morvan') is a rural commune in the Saône-et-Loire department in the Bourgogne-Franche-Comté region in central-east France. As of 2023, the population of the commune was 272. It covers an area of 30.59 km<sup>2</sup> (11.81 sq mi).
There has been a church in Roussillon-en-Morvan since the 9th century, as the village is located on the former Gallo-Roman road between Autun and Orléans via Château-Chinon, which runs through the forests of Glenne and Folin. The commune is part of Morvan Regional Natural Park.