Rouse High School was established in 2008 by the Leander Independent School District in Leander, Texas to relieve overcrowding in the quickly growing district. It is named after Charles Rouse, a former principal at Leander High School. When the school first opened in 2008, it had only a freshman class. However, in its fourth year, the school was opened to seniors, juniors, sophomores, and freshman, which eventually lead to them growing to a 5A classification under the UIL format. In 2011, the school was rated "Academically Acceptable" by the Texas Education Agency.
The demographic breakdown of the 2,460 students enrolled for the 2025-2026 school year was: