The Roman Catholic Diocese of Trujillo (erected 3 July 1987) is a suffragan of the Archdiocese of San Pedro Sula.
The Diocese of Trujillo was founded as the Diocese of Honduras; in 1561, the Diocese of Comayagua was established on territory split off from the Diocese of Trujillo and in 1571 gained its mother bishopric's remaining territory at its suppression (Trujillo would however be restored in 1987).