The Roman Catholic Archdiocese of Los Altos Quetzaltenango-Totonicapán () is a Latin Metropolitan Archdiocese in Guatemala.
The archiepiscopal seat is Quetzaltenango Cathedral (), initially built in Quetzaltenango in 1535. It also has a co-cathedral, San Miguel Arcángel, in Totonicapán.
It was vacant until named Mario Alberto Molina Palma on July 14, 2011; having been headed until Monday, October 4, 2010, by Archbishop Oscar Julio Vian Morales, who Pope Benedict XVI then named to succeed Cardinal Quezada as Metropolitan Archbishop of Guatemala.
It was erected on 27 July 1921 as the Diocese of Quetzaltenango, Los Altos, on territory split off from Guatemala's Metropolitan Roman Catholic Archdiocese.
On 10 March 1951, it lost territory to establish the Diocese of San Marcos and the Diocese of Sololá-Chimaltenango, both of which became its suffragans.
It was elevated and renamed Archdiocese of Los Altos Quetzaltenango-Totonicapán on 13 February 1996. It lost more territory on 31 December 1996 to establish the Diocese of Suchitepéquez-Retalhuleu, another suffragan.
Its ecclesiastical province comprises the Metropolitan's own Archdiocese and the following suffragan dioceses :
The Archdiocese covers the departments of Quetzaltenango and Totonicapán. It has 28 parishes, 29 diocesan priests, 24 religious priests, 57 friars and 118 nuns.
(all Roman Rite)