The Roman Catholic Diocese of Mukachevo () is a diocese of the Latin Church of the Catholic Church in Ukraine. Mykola Petro Luchok, O.P. is the current bishop of the diocese. He was appointed to the See of Mukachevo (Hungarian: Munkács) in 2019.
The history of the diocese begins 1993 when the Apostolic Administration of Zakarpattia (Latin Name: Transcarpatiae Latinorum) was split off from the Diocese of Szatmár. This is unique among the Ukrainian dioceses, the remainder of which were all split off from Lviv, which has been associated with Polish culture. Mukachevo Roman Catholics are mostly members of the Hungarian minority in Ukraine. Elevated to a diocese in 2002, its first bishop was Antal Majnek until 28 January 2022.
The diocese is a suffragan of the Archdiocese of Lviv of the Latins.