Rock Creek is a river in Carbon and Albany counties in Wyoming, United States, that is a tributary of the Medicine Bow River.
The drainage basin of Rock Creek starts high on the north side of the Snowy Range. At the northern base of the range, Rock Creek runs through the census-designated place of Arlington and continues on through the unincorporated community of McFadden and the town of Rock River. From there, Rock Creek runs primarily northeasterly before turning to the northwest and meeting with the Medicine Bow River just north of the town of Medicine Bow.