Rock Branch (also called Rock Creek) is a stream in the U.S. states of Missouri and Oklahoma. It is a tributary of Fivemile Creek.
The stream headwaters arise at approximately five miles southwest of Joplin and one mile south of I-44. The stream flows to the southwest roughly parallel to I-44. The stream confluence with Fivemile Creek is in Oklahoma at and just under one half mile west of the Missouri-Oklahoma border.
Rock Branch was so named on account of the rocky character of its creek bed.