Roccamandolfi is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about southwest of Campobasso and about southeast of Isernia.
Roccamandolfi borders the following municipalities: Cantalupo nel Sannio, Castelpizzuto, Gallo Matese, Letino, Longano, San Gregorio Matese, San Massimo and Santa Maria del Molise.