The Hondo River () is a river of Hormigueros, Puerto Rico. It runs through the municipalities of Hormigueros, Mayagüez, and Cabo Rojo.
The Hondo River is classified as a stream in the region and forms part of the local hydrographic network of western Puerto Rico, contributing to the islandâÂÂs watercourses. It is situated at a low elevation close to sea level and is catalogued in geographic databases that record features of rivers and streams across the territory.