Ribonucleoside-triphosphate reductase (, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase. This enzyme catalyses the following chemical reaction
Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.