Rhamphochromis macrophthalmus is a species of piscivorous cichlid endemic to Lake Malawi where it prefers open waters at depths of from . This species can reach a length of SL. It can also be found in the aquarium trade. FishBase treats this species as a valid species, but the Catalog of Fishes treats it as a synonym of Rhamphochromis longiceps, as does the IUCN.