The Redknife River is a river in the Northwest Territories of Canada. It is a major tributary of the Mackenzie River.
The Redknife Formation, a stratigraphical unit of the Western Canadian Sedimentary Basin was named for the river.
The Redknife river originates in the Redknife Hills, at an elevation of . It flows east down the slopes of the hill, then turns north, draws water from a lake system, then turns north-east. It is crossed by the Mackenzie Highway, then turns north and flows into the Mackenzie River at an elevation of , downstream from Fort Providence and upstream from Jean Marie River.