Rauwolscine, also known as isoyohimbine, ñ-yohimbine, and corynanthidine, is an alkaloid found in various species within the genera Rauvolfia and Corynanthe (including Pausinystalia). It is a stereoisomer of yohimbine. Rauwolscine is a central nervous system stimulant, a local anesthetic and a vague aphrodisiac.
Rauwolscine acts predominantly as a ñ<sub>2</sub>-adrenergic receptor antagonist. It has also been shown to function as a 5-HT<sub>1A</sub> receptor partial agonist and 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> receptor antagonist.