In molecular biology, the RNase E 5â² UTR element is a cis-acting element located in the 5â² UTR of ribonuclease (RNase) E messenger RNA (mRNA).
RNase E is a key regulatory enzyme in the pathway of mRNA degradation in Escherichia coli. It is able to auto-regulate the degradation of its own mRNA in response to changes in RNase E activity. This rne 5â² UTR element acts as a sensor of cellular RNase E concentration enabling tight regulation of RNase E concentration and synthesis.