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MRNA (guanine-N7-)-methyltransferase

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-<small>L</small>-methionine + G(5')pppR-RNA S-adenosyl-<small>L</small>-homocysteine + m<sub>7</sub>G(5')pppR-RNA (mRNA containing an N<sup>7</sup>-methylguanine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.

Nomenclature

The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:

  • messenger ribonucleate guanine 7-methyltransferase,
  • guanine-7-methyltransferase,
  • messenger RNA guanine 7-methyltransferase, and
  • S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
  • cap MTase

See also

References

Further reading